New lignan glycosides from Chinese medicinal plant, Sinopodophillum emodi.

نویسندگان

  • Changqi Zhao
  • Akito Nagatsu
  • Keiichiro Hatano
  • Naohiro Shirai
  • Setsuko Kato
  • Yukio Ogihara
چکیده

Two new podophillotoxin glucosides, L-picropodophillotpxin 7'-O-(beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside) (2) and L-picropodophillotpxin 7'-O-beta-D-glucopyranoside (3), were isolated from Chinese medicinal plant, Sinopodophillum emodi, together with 4 known compounds, podophillotoxin (1), podorhizol 4'-O-beta-D-glucopyranoside (4), deoxypodophillotoxin (5), and dehydropodophillotoxin (6). The structures of 2 and 3 were finally determined by the extensive decouping and nuclear Overhauser effect (NOE) experiments in NMR spectra and circular dichroism (CD) spectra. Compound 2 is the second example of podophillotoxin diglucoside, and both the first one and 2 were isolated from S. emodi. X-ray crystal structure analysis of 1, 5, and 6 was carried out. Compounds 1 and 5 showed the different conformations from those reported.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 51 3  شماره 

صفحات  -

تاریخ انتشار 2003